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Depiction of side effects of Covid-19 vaccines in Czech television news
Zelbová, Judita ; Klabíková Rábová, Tereza (advisor) ; Křeček, Jan (referee)
This thesis focuses on how the side effects of vaccination against covid-19 were presented by media during the pandemic. The aim was to find out how the side effects were reported by Czech national television stations in their evening news programmes, what were the differences in presentation between the stations and which experts were invited to comment on the topic. The thesis primarily uses qualitative content analysis and to a lesser degree quantitative content analysis. The thesis shows that three of the four TV stations studied (ČT1, Nova and Prima) approached the presentation of the topic in a very similar way conceptually, TV Barrandov being quite different in this respect. All TV stations presented side effects on the basis of substantiated data, with an emphasis on information obtained from relevant organisations (European Medicines Agency, Czech State Institute for Drug Control) and experts (mostly epidemiologists, immunologists and physicians of various specialties). Contrary to the expectation, the coverage of the side-effects proved to be relatively marginal and only became notable in the spring of 2021, when a larger number of adverse reactions occurred with the AstraZeneca vaccine.
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Caring for blood cancer patient undergoing chemotherapy
BAIERLOVÁ, Angélique
The basic haemato-oncological diseases include leukaemia, malignant lymphomas, myeloproliferative diseases and myelodysplastic syndrome. The treatment of these diseases is most often carried out with the help of chemotherapy, which, in addition to its therapeutic effect, also has a number of side effects that may reduce the patient's quality of life. During treatment, the role of the nurse is important, ensuring the safe application of chemotherapy, caring for venous access, monitoring the side effects of treatment and participating in patient education. The aim of the bachelor thesis was to find out the specifics of nursing care of a haemato-oncological patient during chemotherapy. The practical part was processed using a qualitative research survey. The first research group consisted of six nurses working in an oncology centre or inpatient department. The second research group consisted of six haemato-oncological patients undergoing chemotherapy. The semi-structured interview became the technique of data collection. The results of the research show that the nurses treat long-term venous accesses insufficiently. Problems were also found in the treatment of extravasations and in the application of the cytostatic drug itself. The results also showed that nurses do not use the right protective equipment when handling cytostatics. Another negative finding was that patients did not have enough information about the prevention of the side effects of chemotherapy and did not have sufficient psychological support from the nurses. Nevertheless, they evaluate the provided care positively. Based on the results, an information brochure designed for haemato-oncological patients undergoing chemotherapeutic treatment was designed as part of the thesis.
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Methods for Predicting Drug Side Effects in Silico
Cicková, Pavlína ; Lexa,, Matej (referee) ; Berka,, Karel (referee) ; Provazník, Ivo (advisor)
Vývoj a výzkum léčiv je oblastí současné vědy, jejíž nedílnou součástí je i využití výpočetních metod. Z důvodu nákladnosti a časové náročnosti laboratorních přístupů, metody in silico sehrávají svou významnou roli. I přes rychlý vývoj výpočetních technik využívaných při vývoji léků, však není drtivá většina zkoumaných molekul v procesu vývoje úspěšná a do schvalovací fáze nepostoupí. Nejen proto se nejmodernější strategie návrhu potenciálních nových léčiv zaměřují na opětovné zkoumání již schválených léků a berou do úvahy i analýzu podobností. Tato práce popisuje vývoj a aplikaci souboru několika workflow, jež byl vytvořen v rámci analytické platformy KNIME a jež implementuje metody strojového učení za účelem predikce nežádoucích účinků léčiv. Součástí prezentovaných workflow je získání dat, jejich předzpracování, výpočet metrik podobností a provedení explorační analýzy. Následně je využito klasifikačních modelů k predikci specifických nežádoucích účinků léčiv. Tato predikce vychází z principů technik založených na podobnosti. K natrénování modelů rozhodovacích stromů pro predikci potenciální asociace nežádoucích účinků s léčivy byly využity strukturní a jiné podobnosti schválených molekul léčiv. Hlavní přínos práce spočívá především v přenositelnosti použitých metod. Soubor workflow je určen k využití jako vhodný nástroj k řešení výzkumných otázek ohledně podobnosti léčiv a jelikož analytická platforma KNIME poskytuje uživatelsky přívětivé grafické rozhraní, není nutné, aby měli uživatelé pokročilé zkušenosti v oblasti strojového učení nebo programování, aby mohli soubor navržených workflow v rámci této platformy pro své analýzy využít.
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Side Effects of UN Peacekeeping missions
Menšíková, Jana ; Střítecký, Vít (advisor) ; Bureš, Oldřich (referee)
Diploma thesis Side Effects of UN Peacekeeping Missions deals with negative sid e ef f e cts of UN peacekeeping operations. The work aims at showing the relation between certain factors and the emergence of the side eff ect s. To do so, four interpretative case studies are used in this thesis. The missions analysed in the case studies share some common characteristics (type of mandate, time period etc.) but differ in the essence of the si de e ff e cts that has been detected during their deployment. For the sid e eff e ct s of human trafficking the UN mission UNMIBH in Bosnia and Hercegovina was analysed, for sexual abuse it was the MONUC in DRC, for diamonds smuggling the UNAMSIL mission in Sierra Leone and for the collaboration with warlords the UNPROFOR in Bosnia and Hercegovina. The applied factors are divided between external (presence of the s id e ef f e cts, the stage of conflict and the efficiency of the central government) and internal (national composition of the mission, level of corruption among the TCC's and the existence of SOFA) and are considered within the context of each case study. This work proofs the relevance of this factors in regard to the emergence of the s id e eff ec ts of peacekeeping.
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Nutritional recommendations during cancer chemotherapy
Balcarová, Kateřina ; Maruna, Pavel (advisor) ; Živný, Jan (referee)
This bachelor thesis investigated the nutritional recommendations during cancer chemotherapy. The aim of this study was to determine whether the side effects of chemotherapy affect the dietary intake of a cancer patient. Apart from that, several goals were set. Firstly, to determine the awareness of oncologic patients treated with chemotherapy about nutritional recommendations that could influence the side effects of this therapy. Secondly, to investigate whether they act in accordance with these nutritional recommendations and to detect the source which is commonly used. Finally, to summarize the information about cancer treatment focusing on chemotherapy, its side effects and nutritional recommendations for them. The research was conducted in the oncology department of the Jablonec nad Nisou Hospital lasting from January to February in 2021. The data were collected anonymously by the non-standardized questionnaire. This questionnaire was given to the patient in the outpatient clinic and collected the next day when the patient attended the treatment. The research group involved adult oncology patients undergoing chemotherapy within the last 3 months. The total research group contained 37 patients, 20 women and 17 men were involved. The research focused on the relationship between chemotherapy and...
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The influence of individual genetic predisposition to the pharmacokinetics and pharmacodynamics of chosen opioids
Matoušková, Olga ; Perlík, František (advisor) ; Votava, Martin (referee) ; Mičuda, Stanislav (referee)
MUDr. Olga Matoušková - the dissertation theses The influence of individual genetic predisposition to the pharmacokinetics and pharmacodynamics of chosen opioids ABSTRACT Introduction: The aim of this thesis is to study the influence of polymorphism of CYP2D6 and MDR1 on the pharmacokinetics and pharmacodynamics of tramadol in healthy volunteers using measurement. A secondary objective is to evaluate these polymorphisms in relation to the analgesic efficacy and side effects of piritramide for acute postoperative pain. Materials and methods: In two prospective work studying the influence of genetic predisposition on the pharmacokinetic and pharmacodynamic parameters of tramadol, we included a total of 90 healthy volunteers. Clinical studies on opioid analgesia and influence of genetic predisposition to the pharmaco-therapeutic effects and side effects in patients with acute postoperative pain, we included a total of 161 patients with acute postoperative pain. Polymorphism genotyping CYP2D6 and MDR1 gene we performed PCR - RFLP analysis, to determine concentrations of tramadol and metabolite, we used gas and liquid chromatography and pharmacodynamic effects of opioids was evaluated by pupilometric measurement and visual analogue scale. Results and conclusion: Variability of the opioid effect is influenced by...
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Adverse effects of epilepsy medication in children
Arnošová, Karolína ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and medicinal sciences Candidate Karolína Arnošová Consultant doc.MUDr. Josef Herink DrSc. Title of thesis Adverse effects of epilepsy medication in children The aim of this thesis was to determine the most commonly used antiepileptics in children, its adverse effects and to compare these results with the adult epileptology. In the theoretical part there are etiopathogenesis, pathophysiology, clinical manifestation, types of the seizures and epileptic syndromes described. The specifics of epilepsy treatment in children, not only pharmacotherapy, but also non-pharmacological treatment options, were documented as well. In the study there was exact half of patients treated with monotherapy and the other half with combined therapy which is not in line with the original hypothesis that assumed a predominance of monotherapy. The most commonly used antiepileptics in children were valproate (62,5 %), lamotrigine (25 %), topiramate and levetiracetame (both in 18,75 %). The hypothesis assuming a higher incidence of adverse effects in combination therapy has been confirmed. The most common adverse effects in children were the effects on total daily activity, occuring in 83,33 %, even with the mildest score on average....
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Substance abuse among the top bodybuilders in the Czech Republic
Hoffmanová, Jana ; Harsa, Pavel (advisor) ; Šejvl, Jaroslav (referee)
In the last few years, the interest in bodybuilding has increased but unluckily it is often accompanied by taking doping substances. At this time, we have been already informed about anabolic steroids exclusively through the media spreading the news about the doping scandals of top athletes. Although many books were written about doping and bodybuilding, their first publishing was dated to 2000 and the literature today mainly focuses on nutrition and training. The goal of my thesis was to map the view of top bodybuilders on doping at the professional and hobby level and their knowledge of the effects of prohibited substances. The qualitative research was made by the series of dialogues that were semi-structured and with the agreement of respondents. The information was recorded on a dictaphone, transcribed and edited. The main research questions were based on the risks that are bodybuilders aware of, their motivation for the sports and possible use of the prohibited substances. They were also asked about their experience of the addiction to them. According to the research, the athletes are well-informed about all the risks. The majority of them are regular users of excessive amount. The motivation for the bodybuilding and taking doping is different, but they have something in common. It is the...
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Opinions of the adult population about mandatory and optional vaccination in the Czech Republic
NEDBALOVÁ, Martina
For my bachelor thesis, I have chosen the topic of Adult Population Opinions on Mandatory and Optional Vaccination in the Czech Republic. The thesis is divided into theoretical and practical part. In the theoretical part I deal with the history of vaccination, basic concepts related to vaccination, composition of vaccines, and distribution of vaccines. A separate chapter is vaccination under the National Immunization Program, i.e. all mandatory, regular vaccinations. Out of the optional vaccinations we take a closer look at vaccination against flu and vaccination against cervical cancer, which are vaccinations around which there are many unanswered questions. The last chapters deals with the side effects of vaccination and negative attitudes of people towards vaccination, where I quote mainly the views of doctors who are against vaccination. The theoretical part is followed by the practical part for which I've set three goals. The primary objective is to find out what is the opinion on compulsory and optional vaccinations in the Czech Republic in the adult population. I also try to find out whether there are people in the population who do not agree with the vaccination. The final objective is to find out what are the vaccination rates for optional vaccines. Part of the thesis is quantitative research based on the questioning method. The questionnaire is based on research assumptions and has been published on the Internet. In one month, 366 respondents answered the questionnaire. The results are presented in form of graphs. My bachelor thesis can help you to better understand the issues concerning vaccination, to deepen the knowledge and, last but not least, to reflect on and build your own opinion on this controversial topic.
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Natrural substances with toxic and allergic activity
Rapiová, Vendula ; Tůmová, Lenka (advisor) ; Kašparová, Marie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Supervisor: doc. PharmDr. Lenka Tůmová, CSc. Student: Vendula Rapiová Title of Thesis: Natural substances with toxic and allergic activity Keywords: medicinal plant, allergy, side effects, toxicity The connection between herbs and mankind dates to early ages and without discussion herbal remedies were the first one to put in use. We observe significant increase of herbal remedies used in paediatric patients in last decades. The goal of this work was set to examine available information about herbal safety. The list of herbs that are dangerous or inappropriate to use in children age was made. The herbs were grouped into simple classification system of herbal safety. In addition to chapters describing herbal safety the work contains knowledge about their general use in paediatrics phytotherapy, the pros and cons of their use. To gather the data of web research and scientific literature were employed. The analysed data were published between 1968-2017 and were collected using PubMed, ScienceDirect and Google Scholar. The rate of herbal safety is classified into five specific groups - A, B, C, S and X. The analysis of results shows that the biggest group with the most represented samples in class was the class C with...
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